The Imaging, Image Analysis and Statistical Analysis Resource will be used to support the research projects and to develop innovative imaging strategies and imaging agents. This resource will play the following roles in the JHU ICMIC: 1. To identify and develop novel imaging approaches for molecular and functional imaging using MR, PET and Optical Imaging. Identification and development of novel imaging approaches will occur through semi-weekly interactions with the leaders of the Research Components and the Developmental Projects, and with key imaging personnel. These interactions will occur either at formal group meetings, or through our web site which will have an interactive forum. 2. To train and assist investigators in the use of imaging technologies and guide investigators in the use of the most relevant imaging technology for the proposed project. Training of investigators will occur through formal mechanisms such as teaching lectures and practical training courses from the leading imaging scientists of the center. 3. To assist and develop new concepts in image analysis and visualization. Within our center the image analysis and visualization component will not only act as a supporting infrastructure for our research, but as an integral part of our multidisciplinary program. 4. To incorporate strategies for combining gene microarray analyses with image analysis. We anticipate a significant amount of gene microarray analyses studies to be performed in combination with our imaging studies. 5. To guide and assist investigators in the statistical analyses of research studies. We have included an expert in statistical analyses in this resource component to guide and assist investigators in statistical analyses.